ADORA2A and neuroblastoma: In line with this, the blockade of both A1R and A2AR was responsible for beneficial effects of caffeine in human neuroblastoma SH-SY5Y cells exposed to Aβ25-35 alone [82] or combined with AlCl3 [83], probably because A1R blockade might potentiate A2AR-mediated protection by promoting the recovery of Ca2+ homeostasis [83].