We investigated nuclear morphology in SUN1 + 2 KD tumor cells, and found that cells showed irregular nuclear morphology with multiple lobes, folds and membrane invaginations in both 1D and 2D (Figure 6D, and Figure S6C–E, Movies S10 and S11), indicative of compromised nuclear mechanotransduction due to defects in nucleo-cytoskeleton integrity. This evidence concerns the gene SUN1 and neoplasm.