tEVs can also have a significant impact on the function and the behavior of endothelial cells: it was demonstrated that the incorporation of EGFR-containing EVs by endothelial cells leads to the activation of the MAPK and Akt pathway and triggers the endogenous expression of vascular endothelial growth factor (VEGF) signaling, stimulating tumor angiogenesis [101]. Here, AKT1 is linked to neoplasm.