Berg et al., using low density lipoprotein receptor (Ldlr) knockout mice and 3-HAAO inhibition show that increasing 3-HANA levels decreases inflammasome activation in macrophages and decrease hyperlipidemia in this mouse model of obesity suggesting 3-HAAO as a novel target for combatting cardiovascular disease, one of the biggest risk factors for stroke patients [147]. This evidence concerns the gene LDLR and obesity due to melanocortin 4 receptor deficiency.