In fact, it has been shown that sorcin interacts with presenilin 2, a component of the γ-secretase, which is involved in the generation of 39–42 amino acid amyloid-β peptides (Aβ) from cleavage of the Aβ protein precursor in Alzheimer’s disease (AD) [20]. The gene discussed is PSEN2; the disease is Alzheimer disease.