Several studies propose its involvement in Ca2+ homeostasis, cell cycle regulation and vesicle trafficking, diabetes, infertility and nervous system pathologies (reviewed in [40]), although most studies on sorcin are related to its overexpression in tumor cells [2,40,41] and to its regulatory role in excitation–contraction coupling in the heart through its interaction with several proteins, such as the SERCA pump [16], the ryanodine receptor intracellular Ca2+ channel [15,42], the Na+-Ca2+ exchanger [18] and L-type Ca2+ channels [43]. Here, SLC8A1 is linked to diabetes mellitus.