The interaction of sorcin with exogenous Aβ and with tau also explains the positive effects of sorcin observed in viability and apoptosis assays, as well as the lack of PMCA inhibition observed in human neuroblastoma SH-SY5Y cell membranes after co-treatment with sorcin and Aβ or sorcin and tau. This evidence concerns the gene MAPT and neuroblastoma.