Resubstituting Ago2 in the AF525 cell line through transfection of a myc-Ago2 expression construct prior to SFV6-2SG-Nluc infection (MOI 0.5), resulted in a decrease in luciferase compared to control cells (transfection of myc-eGFP construct, Figure 6B). The gene discussed is AGO2; the disease is infection.