A study in mice has shown that genetic over-expression of FKBP5, in combination with early life stress, significantly exacerbated anxiety behavior during stress exposure compared to controls, however, mice who were ex-posed to early life stress showed significantly lower levels of FKBP5 in the dorsal hippocampus compared to same-mutated mice who did not experience early life stress [107]. Here, FKBP5 is linked to Anxiety.