(3) PTSD phenotype rats exhibited long-term regionally distinct alteration of the signaling of GR-MR-FKBP5 in the hippocampus and in the hypothalamic nucleus in response to PSS, attenuated GR and MR, complemented by elevation in FKBP5, expression in the ventral hippocampus and PVN, and augmented GR and MR complimented by a decrease in the FKBP5 expression in the dorsal hippocampus. Here, FKBP5 is linked to post-traumatic stress disorder.