Four mRNAs (mRNAs: CCDC88A, ARF6, Vav3, and WASF2) and five small nucleolar RNAs (snoRNAs) (SNORA14B, SNORA18, SNORA25, SNORA74A, and SNORD22) were analysed in circulating EVs from patients with PC and controls. Here, ARF6 is linked to pachyonychia congenita.