TNF and Arthritis: In another arthritis rat model induced by type II collagen, compound 32 inhibited paw swelling and arthritis scores, decreased serum pro-inflammatory factor levels of TNF-α, IL-1β, IL-6, IL-10, IL-12 and IL-17A, down-regulated the expression of JAK1, JAK3 and STAT3, and up-regulated NF-κB p65 and IκB [26].