Recently, the antidepressant effects of curculigoside were reported, and related research revealed that curculigoside (32) improved depression-like behavior in mice, and significantly up-regulated the levels of BDNF protein, as well as the concentrations of DA, NE and 5-HT in the hippocampus of depressive animals [76,77]. The gene discussed is BDNF; the disease is major depressive disorder.