In addition, elastic deformations of tumour cells are needed during the intravasation and extravasation processes to facilitate the penetration of cells through the endothelial cell–cell junctions, and TG2 likely plays a role in this, since it is linked to the intracellular tension of cancer cells through the loss of EGFR-mediated inhibition of cell contractility [195]. The gene discussed is TGM2; the disease is neoplasm.