Hence, the loss of the TG2 at the tumour–stromal interface alters matrix modulation and decreases the cell–matrix interaction, which in turn reduces adhesion and promotes cell motility and invasion [215,216], and it is intriguing that a number of studies identify down-regulation of TG2 in association with invasion and metastasis [47,217,218]. The gene discussed is TGM2; the disease is neoplasm.