Since TG2 plays an important role in mediating cell tension and contractility, with implications for cancer cell motility [100], and as cell stiffness has also been linked to cell uptake capability [252], there could be great interest in fully characterising TG2, EVs, and cancer progression and whether these mechanisms could directly feed into the influence of EVs on cancer progression and the cell substrates and enzymatic functions involved. The gene discussed is TGM2; the disease is cancer.