As disorders in JAK-STAT signalling pathway genes are a very common finding in many forms of T-cell lymphoma, mostly with a cytotoxic phenotype, current evidence suggests that they may have a possible role in the pathogenesis of this disorder [17,21,33]; however, such alterations were not seen in the CD8+ cases of the series [21], which share a cytotoxic phenotype with many of those T-cell lymphomas. Here, CD8A is linked to T-cell non-Hodgkin lymphoma.