Zearalenone or its metabolic compounds are known to bind transcription factors, including pregnane X receptors involved in expressing enzymes in pathways of biosynthesis; zearalenone chronic administration can cause uterine fibroids, pituitary adenomas, hepatocellular carcinoma, and liver damage in mice, and chronic progressive hematotoxicity, testicular atrophy, cataracts, retinopathy, and nephropathy in rats; among other animals, pigs are more prone its toxicities. The gene discussed is NR1I2; the disease is hepatocellular carcinoma.