SFRP2 and gastric carcinoma: Previous studies found that the methylation levels of SFRP2 in gastric carcinoma were lower than adjacent non-cancer samples, and overexpression of SFRP2 in vivo can inhibit the proliferation of tumor cell and induce cell apoptosis, demonstrated that the methylation of SFRP2 is an early event in the process of GC [27].