IFNα-inducible protein 6 (IFI6, aka IFI-6-16, or GIP3) is a member of a conserved protein family that consists of IFI6, IFI27 (ISG12a), IFI27L1 (ISG12c), and IFI27L2 (ISG12b) [106], and it was first characterized as a cellular gene induced by the IFN response and virus infections [107,108,109]. This evidence concerns the gene IFI27L2 and viral infectious disease.