THBS1 and pulmonary arterial hypertension: For instance, plasma TSP1 in patients with pulmonary hypertension can be as high as 1114 ± 136 ng/mL compared to controls at 82 ± 16 ng/mL [39] and 571 ± 226 ng/mL in acute ischemic stroke (AIS) versus 146 ± 50 ng/mL in control [40].