These beneficial effects appear to be attributed to the activation of SIRT1 with consequent fiber shift from fast-to-slow twitch, which, as mentioned before, prevents muscular dystrophies [40,55].The optimal dose of resveratrol treatment in most of the experiments is shown to be 100 mg/kg/day [8,40,41,53,55]. Here, SIRT1 is linked to muscular dystrophy.