PPARGC1A and Duchenne muscular dystrophy: Capogrosso et al. studied the effect of some natural compounds, such as resveratrol, taurine and apocynin, in ameliorating DMD pathophysiology, compared to α-methyl prednisolone (PDN), a corticosteroid largely used in this disease [8].The treatment lasted 4–5 weeks and the administration of these natural activators of SIRT1/PGC-1α pathway, in particular resveratrol at a dose of 100 mg/kg5 days/week, led to a reduction in superoxide anion production and to decreased plasma levels of creatine kinase and lactate dehydrogenase, hence muscle force is increased [8].