WNK2 and cancer: This mutation leads to a constitutive activation of the mitogen-activated protein kinase kinase (MEK)-extracellular-regulated kinase (ERK) signalling pathway of the mitogen-activated protein kinases (MAPKs), which in turn, results in different hallmarks of cancer; increased proliferation, upregulation of migration, invasion and protection from apoptosis [10,11,12,13,14].