In contrast, HAS2 knockdown reduced MK2 phosphorylation in cells, indicating a feedforward loop between MK2 activation and HAS2 expression; (3) BLM induced collagen deposition-associated lung fibrosis, the upregulation of HAS2 mRNA expression, and an increase in HA production, all of which were sensitive to MMI-0100; and (4) after the BLM instillation, fibroblasts carrying a specific deletion of the Mk2 gene showed decreased HA production, reduced HAS2 mRNA expression, and suppressed invasion capacity, compared to fibroblasts from the WT littermates [92]. Here, HAS2 is linked to pulmonary fibrosis.