In comparison with other published pan-cancer datasets, including The Cancer Genome Atlas (TCGA), the Pan-Cancer Analysis of Whole Genomes (PCAWG), and the recent data releases for the Genomics Evidence Neoplasia Information Exchange (GENIE) 8.1 and TCGA 27.0, there was significant variation in top somatic mutation frequencies of TP53, APC, KRAS, and LRP1B genes [20,21,22,23]. The gene discussed is LRP1B; the disease is cancer.