Interestingly, reduced Drp1 level in retinas of diabetic Drp1+/− mice showed a decrease in diabetes-induced Bax expression (113 ± 19% of WT, p < 0.01; n = 12; Figure 4A,B), PARP cleavage (112 ± 28% of WT, p < 0.01; n = 12; Figure 4A,C), and caspase-3 activation (102 ± 8% of WT, p < 0.01; n = 12; Figure 4D). This evidence concerns the gene CASP3 and diabetes mellitus.