In thyroid tumors, angiogenesis is activated and maintained by the modulation of the genes involved in angiogenesis and response to hypoxia (HIF1A, TUFT1, BHLHB2), cell survival (RIPK5), proliferation (PTGS2, DUSP5), apoptosis (ZFP36L1, IER3), metabolism (SLCA2A3), cell organization (RAB7B) and protein degradation (SKP1, KLK-4) in the ST surrounding the tumor cells [39]. This evidence concerns the gene HIF1A and neoplasm.