FGF2 and neoplasm: TAMs contribute to angiogenesis of tumors with an increased production of proangiogenic factors, such as vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), and basic fibroblast growth factor (bFGF), and produce a high amount of matrix metalloproteases (MMPs), which are responsible for ECM remodeling and facilitate tumor cells spread and invasion [28,29].