Interference of Aurora proteins, FOXM1, KIF11 and PLK1 showed promising results in vitro and in vivo in HNSCC, but these molecular targets are currently not tested in HNSCC in clinical trials [107,109,127,188,195,196,197,198,199,200,201,202,203,204]. This evidence concerns the gene KIF11 and head and neck squamous cell carcinoma.