In several reports the susceptibility of HNSCC to Chk1 and Wee1 inhibitors has been published (Table 1) [107,110,111,112,121,126,193,198,209,215,216,217,218,219,220,221,222,223,224,225,226,229,230,231,232,233,234,235,236,237]. The gene discussed is CHEK1; the disease is head and neck squamous cell carcinoma.