As shown in other tumor types (reviewed in [246]), inhibitors targeting molecules such as ATR, Wee1 and Chk1, which induce replication-associated DNA damage and potentially cGAS/STING pathway activation through subsequent cytosolic DNA fragments in HNSCC, are promising candidates for combination treatments in HNSCC. The gene discussed is WEE1; the disease is head and neck squamous cell carcinoma.