ENG and osteosarcoma: Table 3 further corroborates the DK1 anti-metastatic potentials toward osteosarcoma cell lines in a protein expression level which pro-metastatic proteins like Endoglin, uPA, IGFBP, and FGF were significantly down-regulated in U-2 OS, while in MG-63 such event also can be observed where the expression of pro-metastatic proteins such as Serpin E1, Endoglin, IGFBP2, and PD-ECGF were decreased significantly.