C1S and age-related macular degeneration: According to further multivariable logistic regression analysis, complement C1s (C1S), adrenomedullin (ADM), and immediate early response 5 like (IER5L) were identified as the diagnostic biomarker candidates for AMD [OR (95%CI): 11.302 (2.485, 655.7), p = 0.003; OR (95%CI): 3.048 (1.368, 7.790), p = 0.011; OR (95%CI): 0.119 (0.293, 0.375), p < 0.001, respectively] (Table 1).