TP53 and neoplasm: The results showed that in FaDu cells treatment with CisPt and/or RSV acted in the sense of amplifying the expression of the TP53 gene, while in PE/CA-PJ49 tumor cells the combined treatment CisPt + RSV led to a decrease of the TP53 gene expression in an antagonist way as compared to the response to CisPt or RSV applied individually (Figure 2A).