MDM2 and neoplasm: The results obtained on PE/CA-PJ49 tumor cells treated for 24 h with 10 μM CisPt applied alone showed that MDM-2 gene expression was not modified compared to untreated cells, while 50 μM RSV induced a significant increase of the MDM-2 gene expression (p < 0.0005, ***), compared to the effect induced by CisPt.