MYCN and neoplasm: In this regard, a variety of clinical and biologic factors have been identified and traditionally used by the Children’s Oncology Group (COG): age at diagnosis, INSS (International Neuroblastoma Staging System) to define the extent of disease, INPC (International Neuroblastoma Pathology Classification) tumor histology criteria, MYCN status, DNA index and segmental chromosomal aberrations (SCA) [18].