FHIT and neoplasm: Three tumor suppressor genes residing on the most active sites of this type are Fragile Histidine Triad Diadenosine Triphosphatase (FHIT) at FRA3B, WW Domain Containing Oxidoreductase (WWOX) at FRA16D and Parkinson Disease-2 (PARK2) at FRA6E [3,4].