This notion is also supported by the fact that IDH1/2 and TET2 mutant AML cells display overlapping hypermethylation signatures, enriched for genes involved in pathways known to contribute to the malignant transformation of hematopoietic cells, such as genes that are direct targets of the GATA1 and GATA2 transcription factors [38]. This evidence concerns the gene IDH1 and acute myeloid leukemia.