ADIPOQ and metabolic disease: Exogenous adiponectin administration using a leptin-deficient ob/ob and high-fat diet-fed mouse model of metabolic disorder was shown to promote ceramidase activity through both AdipoR1 and AdipoR2 activation, thereby improving insulin resistance and preventing caspase-8-mediated apoptosis in pancreatic β-cells, cardiomyocytes, and hepatocytes.