Genomic, transcriptomic, bioinformatic, and omics studies have indicated that aberrant signal transduction pathways including epithelial growth factor (EGF) receptor (EGFR), nuclear factor kappa-B (NF-κB) [11], WNT/β-catenin [12], PI3K/Akt/mTOR, p53, PARP, MAPK, STAT, cell cycle pathways, and miRNAs/lncRNAs [13,14] may result in tumor progression and treatment resistance in NPC. This evidence concerns the gene TP53 and neoplasm.