GLDC and hepatocellular carcinoma: Moreover, the brain is one of the few tissues with naturally high GLDC expression [90], suggesting the inverse tendency in typically non-GCS-expressing tissues that become cancerous and then overexpress GLDC. This can be supported by the findings of Zhuang et al. on hepatocellular carcinoma (HCC), wherein restoration of GCS proper activity (via GLDC overexpression due to its low level in malignant HCC) suppressed cancer progression via inhibition of both invasion and metastasis [91].