More importantly, the latest research reported by Gao et al. [12] confirmed the anti-NSCLC effect of XN, not only in a cell culture system but also in a xenograft mouse model, indicating the importance of downregulation of ERK1/2 activation, as well as Fra1 and cyclin D1 expression in this phenomenon. The gene discussed is FOSL1; the disease is non-small cell lung carcinoma.