AGER and COVID-19: The crosstalk between RAGE and AT1R signaling might be responsible for the inflammatory events and alveolar–capillary barrier disruption in lungs, leading to high-permeability pulmonary edema and alveolar flooding upon SARS-CoV-2 infection (Figure 3), and it might be determinant in predisposing subjects with comorbidities to develop severe COVID-19.