AGER and COVID-19: Finally, RAGE has been involved in the formation of neutrophil extracellular traps (NETs, i.e., extracellular webs made of DNA, histones, microbicidal proteins, and oxidant enzymes) [17] that are released by neutrophils to restrain SARS-CoV-2 infection, and the excess formation of which causes respiratory failure and thrombosis in severe COVID-19 [86].