The levels of AGEs increase in liver and adipose tissue following a high-fat diet, contributing to obesity and promoting the secretion of proinflammatory cytokines (adipokines) from adipose tissue mainly through their interaction with RAGE, sustaining low-grade chronic inflammation and OxS, leading to diabetes, insulin resistance, and CVD [18]. The gene discussed is AGER; the disease is obesity due to melanocortin 4 receptor deficiency.