In diabetes, obesity, and aging, RAGE and its ligands are expressed at high levels in activated inflammatory and endothelial cells, sustaining low-grade systemic inflammation and oxidative stress (OxS), which represent risk factors for the development of vascular inflammation and subsequent atherosclerosis, arterial stiffness, and hypertension, predisposing patients to CVD [16,17]. The gene discussed is AGER; the disease is Obesity.