In these subjects, SARS-CoV-2 entry and replication might lead to the additional release of RAGE ligands and further RAGE activation, reinforcing the AT1R deleterious signaling and generating a positive proinflammatory loop, culminating in ARDS, systemic cytokine storm, defective immune response, and virus escape and diffusion. The gene discussed is AGER; the disease is acute respiratory distress syndrome.