ACSS2 and autoimmune polyendocrinopathy: Thus, Candida can produce large quantities of acetaldehyde and acetyl-CoA synthetase (more in smokers) in cases of potentially malignant disorders and in oral carcinomas (concentrations of acetaldehyde and acetyl-CoA synthetase increase) compared to healthy individuals and those with ectodermal dystrophy and autoimmune polyendocrinopathy (with candidiasis) [72,85,86,87,88,89,90,91].