From this panel, a subgroup of 13 genes is analyzed in those patients with HBOC syndrome: ATM, BRCA1, BRCA2, BRIP1, CHEK2, EPCAM, MLH1, MHS2, MSH6, NBN, PALB2, RAD51C, and RAD51D. CDH1, NF1, PTEN, STK11 and TP53 genes are analyzed when the family meets clinical criteria for it. This evidence concerns the gene NBN and Hereditary breast and ovarian cancer syndrome.