From this panel, a subgroup of 13 genes is analyzed in those patients with HBOC syndrome: ATM, BRCA1, BRCA2, BRIP1, CHEK2, EPCAM, MLH1, MHS2, MSH6, NBN, PALB2, RAD51C, and RAD51D. CDH1, NF1, PTEN, STK11 and TP53 genes are analyzed when the family meets clinical criteria for it. Here, CHEK2 is linked to Hereditary breast and ovarian cancer syndrome.