However, the results of this study suggest that MMP-2 may also be highly upregulated in oral squamous cell carcinomas expressing both NKX2.1 and miR-365, which confirm previous observations of the importance and potential role of MMP-2 upregulation in oral carcinogenesis and pathogenesis, although more research is needed to determine if any mechanisms for direct or indirect modulation can be established [28,29,30]. The gene discussed is MMP2; the disease is oral cavity squamous cell carcinoma.