We investigated, in vivo, the expression of Zeb1, SK3 (a potassium channel), and Orai1/2 (two calcium channels) in tumor samples obtained from 220 patients with hormone naïve clinically-localized cancer (CLC), 50 patients with adenocarcinoma CRPC (CRPC-adeno), and 16 patients with NE CRPC (CRPC-NE). The gene discussed is ORAI1; the disease is neoplasm.