In turn, YAP1 plays critical roles in cardiovascular diseases associated with extensive vessel wall remodelling, including atherosclerosis [59], pulmonary hypertension [60,61] and coronary artery restenosis following angioplasty [46] by accelerating migration of VSMC, increasing proliferation of VSMCs, adventitial fibroblasts and endothelial cells and driving ECM deposition and remodelling [62,63]. The gene discussed is YAP1; the disease is pulmonary arterial hypertension.