ERBB4 and autosomal recessive polycystic kidney disease: In the same way, abnormal expression of EGF [113,114] and transforming growth factor-alpha (TGFα) [115] have been demonstrated in ARPKD, and several members of EGFR family of receptors (EGFR1, ErbB2, and ErbB4) were found overexpressed in ARPKD rodent models [72,116] (Figure 3A).