Indeed, increased levels of Coriobacteriaceae members have been found in conditions of overweight and obesity, as well as in the context of type 2 diabetes and symptomatic atherosclerosis, and directly associated with metabolic risk factors, including those predisposing to MS, such as insulin, triglycerides and LDL cholesterol [15,17,60,76], as also observed in our sample. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.