NOX4 and metabolic dysfunction-associated steatohepatitis: Furthermore, to strengthen the observed correlation between NOX and hepatic liver accumulation, a study investigated the existence of single-nucleotide polymorphisms (SNPs) in the genes encoding NOX4 and p22phox (CYBA) and observed an association between the rs3017887 SNP of NOX4 and a higher ALT concentration in NAFLD patients and also between the AA genotype in the CYBA-675 T/A CYBA polymorphism and higher triglyceride and lower HDL levels in NASH patients [48].