In a mouse model for Alzheimer disease (APP/Presenilin 1 mice expressing human mutant presenilin 1 and a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe)) unilateral nephrectomy increased plasma and brain Aβ deposition and reduced Aβ in urine [6]. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.