In NSCLC, for example, some studies underlined that there is no difference in survival outcomes between low sPD-L1 and high sPD-L1 patients with NSCLC [123], whereas other studies indicated that plasma sPD-L1 (and sPD-L1/sPD-1 ratio) can be positively correlated with overall survival of NSCLC patients [126]. This evidence concerns the gene HOXD13 and non-small cell lung carcinoma.