Campylobacter species have also been found to be enriched in CRC samples [91,92], and studies on germ-free mice haplo-insufficient for the APC gene (ApcMin/+) subjected to dextran sodium sulphate (DSS) reported the development of large tumours in the distal colon of mice infected with a C. jejuni strain carrying a functional CdtB subunit [93]. This evidence concerns the gene APC and colorectal carcinoma.