In contrast, T cells affect bone cells, resulting in increased cancer-induced osteolysis [71] and the release of factors such as TGF-β that can suppress proliferation and function of T cells and their anti-tumor effects by increasing conversion of CD4+ T cells to Tregs, creating immunosuppressive microenvironment and increasing the formation of metastases [71,72,73]. This evidence concerns the gene TGFB1 and cancer.