Since the effect of synuclein expression may vary depending on age, another study used transgenic mice conditionally expressing human wild-type alpha-synuclein in the midbrain and forebrain, and showed that these animals develop nigral and hippocampal neuropathology, including reduced neurogenesis and neurodegeneration in absence of fibrillary inclusions, which was in turn associated with memory impairment in the MWM and progressive motor decline [180]. This evidence concerns the gene SNCA and memory impairment.