To end with genetic models of PD, BAC transgenic rats in which human wild-type α-synuclein was overexpressed display age-dependent accumulation of full-length and C-terminal truncated α-synuclein aggregates into insoluble fibers in the brain (particularly in the STR), along with early disturbances in novelty-seeking (indicative of increased anxiety) [140]. The gene discussed is SNCA; the disease is Parkinson disease.