Consistent with this, Greco et al. detected that HMGA1 and MMP-11 mRNA expressions were higher, as well as the HMGA1 and MMP-11 protein expression levels in the BCC and SCC samples compared to healthy tissue, and the levels of the two markers were higher in SCC compared to BCC, suggesting their involvement in tumor aggressiveness [210]. The gene discussed is HMGA1; the disease is skin basal cell carcinoma.