NFE2L2 and cancer: Sun exposure leads to the alteration of numerous signaling pathways, such as the mitogen-activated protein kinase (MAPK), the nuclear factor-kappa beta (NF-kB), the JAK/STAT (signal transduction and activation of transcription) and the nuclear factor erythroid 2-related factor 2 (Nrf2), as critical networks for modulating inflammation and cancer [140].