Figure 2 shows the interplay of eicosanoids at different stages of the carcinogenesis process in rat melanoma cells B16F10. The mechanism of action of some of the selected inhibitors and B16F10 have been reported for ASA [15,16,17,18,19], MK886 [14], and baicalein [20,21,22,23,24,25]. However, a search in PubMed surprisingly shown almost no data for meloxicam [26], AA-861 or PD-146176 on B16 cells. Of note, there are not reports on the role of 15-LOX on any melanoma cell although some work has been done on other cancer cell lines [27]. This evidence concerns the gene ALOX15 and melanoma.