Olagnier and coworkers showed that SARS-CoV-2 infection induces the expression of genes related to inflammatory and antiviral pathways, including RIG-I receptor and Toll-like receptor signaling, in lung biopsies of COVID-19 patients as well as epithelial and kidney cell lines, and in genes associated to Nrf2 antioxidant response the expression is decreased. The gene discussed is NFE2L2; the disease is COVID-19.