RUNX1 and acute myeloid leukemia: Comparison between the most recent international children and adult genomic risk-stratifications at diagnsosis [1,21] (Table 3) shows that most of the AML genetic subgroups are common and share the same prognosis value; for instance, t(8;21)(q22;q22)/RUNX1-RUNX1T1 and t(6;11)(q27;q23)/KMT2A-MLLT4 are classified within the favorable and adverse risk subgroups, respectively, whatever the age of the patient.