Of note, two-thirds of CBFA2T3-GLIS2 AML cases presented with ACAs, mostly as chromosomal gains leading to hyperdiploid karyotypes (47–49 chromosomes), with trisomy 3 being characteristic and present in 20% of cases, followed by trisomy 21 and gain of the Y chromosome [48,67]. The gene discussed is GLIS2; the disease is acute myeloid leukemia.