Acute myeloid leukemia with t(8;21)(q22;q22)/RUNX1-RUNX1T1 and inv(16)(p13q22) or t(16;16)(p13;q22)/CBFB-MYH11 are referred to as core binding factor (CBF) leukemia. This evidence concerns the gene CBFB and acute myeloid leukemia.