In a recent international collaborative study gathering 153 AMKL cases, t(11;12)/NUP98-KDM5A, inv(16)/CBFA2T3/GLIS2, KMT2Ar and monosomy 7 cases (9%, 16%, 9% and 6% of cases, respectively), defined as the NCK-7 group accounting for 40% of cases, independently predicted a poor outcome. This evidence concerns the gene GLIS2 and acute megakaryoblastic leukemia.