In 2012, a cryptic inversion of chromosome 16, inv(16)(p13.3q24.3)/CBFA2T3-GLIS2, was identified in 27–31% of non-DS pediatric AMKL, thus representing the most frequent aberration found in de novo pediatric AMKL (Table 2 and Figure 2) [121,122]. The gene discussed is GLIS2; the disease is acute megakaryoblastic leukemia.